Document Type
Article
Version Deposited
Published Version
Publication Date
2-6-2025
Publication Title
Cells
DOI
10.3390/cells14030235
Abstract
SUMOylation, the post-translational modification of proteins by small ubiquitin-like modifiers, plays a critical role in regulating various cellular processes, including innate immunity. This modification is essential for modulating immune responses and influencing signaling pathways that govern the activation and function of immune cells. Recent studies suggest that SUMOylation also contributes to the pathophysiology of central nervous system (CNS) viral infections, where it contributes to the host response and viral replication dynamics. Here, we explore the multifaceted role of SUMOylation in innate immune signaling and its implications for viral infections within the CNS. Notably, we present novel proteomic analyses aimed at elucidating the role of the small ubiquitin-related modifier (SUMO) in human immunodeficiency virus (HIV) latency in microglial cells. Our findings indicate that SUMOylation may regulate key proteins involved in maintaining viral latency, suggesting a potential mechanism by which HIV evades immune detection in the CNS. By integrating insights from proteomics with functional studies, we anticipate these findings to be the groundwork for future studies on HIV-host interactions and the mechanisms that underlie SUMOylation during latent and productive infection.
Recommended Citation
Imbert, Fergan and Langford, Dianne, "Comprehensive SUMO Proteomic Analyses Identify HIV Latency-Associated Proteins in Microglia." (2025). Rowan-Virtua School of Osteopathic Medicine Departmental Research. 272.
https://rdw.rowan.edu/som_facpub/272
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Published Citation
Imbert F, Langford D. Comprehensive SUMO Proteomic Analyses Identify HIV Latency-Associated Proteins in Microglia. Cells. 2025; 14(3):235. https://doi.org/10.3390/cells14030235
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Cell Biology Commons, Immunology of Infectious Disease Commons, Medicine and Health Sciences Commons, Molecular and Cellular Neuroscience Commons, Other Cell and Developmental Biology Commons
