Title

Mechanisms of Environmental Chemicals that Enable the Cancer Hallmark of Evasion of Growth Suppression

Authors

Rita Nahta, Emory University
Fahd Al-Mulla, Kuwait University
Rabeah Al-Temaimi, Kuwait University
Amedeo Amedei, University of Florence
Rafaela Andrade-Vieira, Dalhousie University
Sarah Bay, Emory University
Dustin Brown, Colorado School of Public Health
Gloria Calaf, University of Tarapacá
Gloria Calaf, Columbia University Medical Center
Robert Castellino, Emory University
Karine Cohen-Solal, Cancer Institute
Anna Colacci, 10Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy,
Nichola Cruickshanks, Virginia Commonwealth University
Paul Dent, Virginia Commonwealth University
Riccardo Di Fiore, University of Palermo
Stefano Forte, 13Mediterranean Institute of Oncology, 95029 Viagrande, Italy,
Gary Goldberg, Rowan University School of Osteopathic Medicine
Roslida Hamid, 15Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia,
Harini Krishnan, Rowan University School of Osteopathic Medicine
Dale Laird, University of Western Ontario
Ahmed Lasfar, Rutgers University
Paola Marignani, Dalhousie University
Lorenzo Memeo, 13Mediterranean Institute of Oncology, 95029 Viagrande, Italy,
Chiara Mondello, National Research Council
Christian Naus, University of British Columbia
Richard Ponce-Cusi, University of Tarapacá
Jayadev Raju, Health Canada
Debasish Roy, City University of New York
Rabindra Roy, Georgetown University Medical Center
Elizabeth Ryan, Colorado School of Public Health
Hosni Salem, Cairo University
A.Ivana Scovassi, National Research Council
Neetu Singh, King George's Medical University
Monica Vaccari, 10Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy,
Renza Vento, College of Science and Technology
Renza Vento, University of Palermo
Jan Vondráček, 26Department of Cytokinetics, Institute of Biophysics AS CR, Brno 612 65, Czech Republic,
Mark Wade, Istituto Italiano di Tecnologia
Jordan Woodrick, Georgetown University Medical Center
William Bisson, Oregon State University

Document Type

Article

Version Deposited

None (link only)

Publication Date

1-6-2015

Publication Title

Carcinogenesis

DOI

10.1093/carcin/bgv028

Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

Published Citation

Nahta R, Al-Mulla F, Al-Temaimi R, Amedei A, Andrade-Vieira R, Bay SN, Brown DG, Calaf GM, Castellino RC, Cohen-Solal KA, Colacci A, Cruickshanks N, Dent P, Di Fiore R, Forte S, Goldberg GS, Hamid RA, Krishnan H, Laird DW, Lasfar A, Marignani PA, Memeo L, Mondello C, Naus CC, Ponce-Cusi R, Raju J, Roy D, Roy R, Ryan EP, Salem HK, Scovassi AI, Singh N, Vaccari M, Vento R, Vondráček J2, Wade M, Woodrick J, Bisson WH. Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis. 2015 Jun;36 Suppl 1:S2-18. doi: 10.1093/carcin/bgv028. PMID: 26106139. PMCID: PMC4565608.

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