Date of Presentation
5-6-2021 12:00 AM
College
School of Osteopathic Medicine
Poster Abstract
Multiple myeloma (MM) is a malignancy of plasma cells that accounts for approximately 1 to 2 percent of all cancers and about 17% of all hematologic malignancies.
Plasma cells normally produce antibodies and provide a defense mechanism for the body to fight infections.
Antibodies typically consist of two heavy chains (IgG, IgA, IgM, IgD and IgE) and two light chains (kappa and lambda).
Most cases of MM have malignant plasma cells producing monoclonal (M) proteins, most common being IgG about 52% of the time (1).
Only about 2% of these myeloma cases were also found to secrete more than one paraprotein and classified as biclonal/biphenotypic plasma cell myeloma (2).
Here we report a case of a woman who presented with lower back pain that was found to have biphenotypic multiple myeloma with a coexpression of kappa and lambda light chains.
Keywords
Multiple Myeloma, antibodies, plasma, biphenotype, paraproteins
Disciplines
Hematology | Hemic and Lymphatic Diseases | Medicine and Health Sciences | Neoplasms | Oncology | Pathological Conditions, Signs and Symptoms
Document Type
Poster
Included in
Hematology Commons, Hemic and Lymphatic Diseases Commons, Neoplasms Commons, Oncology Commons, Pathological Conditions, Signs and Symptoms Commons
Multiple Myeloma with Dual Expression of Kappa and Lambda Light Chains
Multiple myeloma (MM) is a malignancy of plasma cells that accounts for approximately 1 to 2 percent of all cancers and about 17% of all hematologic malignancies.
Plasma cells normally produce antibodies and provide a defense mechanism for the body to fight infections.
Antibodies typically consist of two heavy chains (IgG, IgA, IgM, IgD and IgE) and two light chains (kappa and lambda).
Most cases of MM have malignant plasma cells producing monoclonal (M) proteins, most common being IgG about 52% of the time (1).
Only about 2% of these myeloma cases were also found to secrete more than one paraprotein and classified as biclonal/biphenotypic plasma cell myeloma (2).
Here we report a case of a woman who presented with lower back pain that was found to have biphenotypic multiple myeloma with a coexpression of kappa and lambda light chains.