Date of Presentation
5-5-2022 12:00 AM
College
School of Osteopathic Medicine
Poster Abstract
Phyllodes tumors are rare, fast growing fibroepithelial tumors of the breast that account for less than 1% of all breast tumors globally. They were first characterized by Johannes Muller in 1838 and most often present in the 5th decade of life. Phyllodes tumors are histologically composed of a stromal component and an epithelial component. The stromal component has a widely accepted malignant potential in up to 30% of cases. Grading of the stromal malignant potential of phyllodes tumors has been defined by the World Health Organization (WHO) as benign, borderline, or malignant based on the presence and degree of stromal cellularity, atypia, mitotic activity, border infiltration versus circumscription and stromal overgrowth. The epithelial component has traditionally been thought to be largely unrelated to invasive cancer pathology, though sporadic cases have been reported of collision between invasive ductal carcinoma (IDC) and phyllodes tumors. We sought to better characterize this rarely reported pathology and better understand its contribution to the global burden of disease.
Keywords
Phyllodes Tumor, Breast Neoplasms, Fibroepithelial Neoplasms, Invasive Ductal Carcinoma, Women's Health
Disciplines
Medicine and Health Sciences | Obstetrics and Gynecology | Pathological Conditions, Signs and Symptoms | Pathology | Skin and Connective Tissue Diseases | Women's Health
Document Type
Poster
Included in
Obstetrics and Gynecology Commons, Pathological Conditions, Signs and Symptoms Commons, Pathology Commons, Skin and Connective Tissue Diseases Commons, Women's Health Commons
Foci of IDC in Phyllodes Tumors: Should We Be Worried?: A Systematic Review of the Literature
Phyllodes tumors are rare, fast growing fibroepithelial tumors of the breast that account for less than 1% of all breast tumors globally. They were first characterized by Johannes Muller in 1838 and most often present in the 5th decade of life. Phyllodes tumors are histologically composed of a stromal component and an epithelial component. The stromal component has a widely accepted malignant potential in up to 30% of cases. Grading of the stromal malignant potential of phyllodes tumors has been defined by the World Health Organization (WHO) as benign, borderline, or malignant based on the presence and degree of stromal cellularity, atypia, mitotic activity, border infiltration versus circumscription and stromal overgrowth. The epithelial component has traditionally been thought to be largely unrelated to invasive cancer pathology, though sporadic cases have been reported of collision between invasive ductal carcinoma (IDC) and phyllodes tumors. We sought to better characterize this rarely reported pathology and better understand its contribution to the global burden of disease.