Date of Presentation

5-5-2022 12:00 AM

College

School of Osteopathic Medicine

Poster Abstract

78-year-old female with past medical history of acromegaly status post pituitary adenoma status post resection presents to the emergency department with abdominal pain. ED workup was not significant for any acute intra-abdominal abnormalities; however, incidental finding of hyperkalemia was pertinent to the visit. Patient was treated in the ED for her condition but her potassium levels remained elevated despite repeated saline infusions. Patient was ultimately admitted to the hospital where it was discovered that she had recently been switched from octreotide injections to an oral somatostatin analogue Mycapssa. We believe that this patient’s hyperkalemia was caused by octreotide-induced insulin suppression and resultant impaired cellular potassium uptake. Although octreotide has a wide variety of medical applications it can/should be used with caution as complications arising from elevated potassium can be potentially dangerous.

Keywords

Octreotide, Hyperkalemia, Somatostatin, Diabetes Mellitus

Disciplines

Amino Acids, Peptides, and Proteins | Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Medicine and Health Sciences | Pathological Conditions, Signs and Symptoms

Document Type

Poster

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May 5th, 12:00 AM

Case report: Octreotide Associated Hyperkalemia

78-year-old female with past medical history of acromegaly status post pituitary adenoma status post resection presents to the emergency department with abdominal pain. ED workup was not significant for any acute intra-abdominal abnormalities; however, incidental finding of hyperkalemia was pertinent to the visit. Patient was treated in the ED for her condition but her potassium levels remained elevated despite repeated saline infusions. Patient was ultimately admitted to the hospital where it was discovered that she had recently been switched from octreotide injections to an oral somatostatin analogue Mycapssa. We believe that this patient’s hyperkalemia was caused by octreotide-induced insulin suppression and resultant impaired cellular potassium uptake. Although octreotide has a wide variety of medical applications it can/should be used with caution as complications arising from elevated potassium can be potentially dangerous.

 

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