Date of Presentation

5-5-2022 12:00 AM

College

School of Osteopathic Medicine

Poster Abstract

• Alzheimer’s disease (AD) is one of the most common form of dementia

• Mild cognitive impairment (MCI), specifically amnestic subtype, more likely to progress to AD

• Pathogenesis Theories:

  • o Accumulation of amyloid-beta peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein
  • o Blood Brain Barrier (BBB) dysfunction is associated with AD pathogenesis

• Brodmann area 39/40: regions of parietal cortex are responsible for language, spatial cognition, memory retrieval, attention, phonological processing, and emotional processing

• Hypothesis: An increased BBB permeability in Brodmann area 39/40 of AD and age-matched MCI and no cognitive impairment (NCI) subjects

Keywords

Alzheimer Disease, Dementia, Blood-Brain Barrier, Parietal Lobe, Brodmann Area 39, Neurofibrillary Tangles, tau Proteins, Amyloid beta-Peptides, Cognition

Disciplines

Medical Cell Biology | Medical Molecular Biology | Medical Neurobiology | Medicine and Health Sciences | Nervous System Diseases | Pathological Conditions, Signs and Symptoms

Document Type

Poster

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May 5th, 12:00 AM

The Brodmann Area 39/40 of the Brain in Alzheimer’s, Mild Cognitive Impairment, and No Cognitive Impairment Subjects at Advanced Age Demonstrate Comparable Levels of Blood-Brain Barrier Breach

• Alzheimer’s disease (AD) is one of the most common form of dementia

• Mild cognitive impairment (MCI), specifically amnestic subtype, more likely to progress to AD

• Pathogenesis Theories:

  • o Accumulation of amyloid-beta peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein
  • o Blood Brain Barrier (BBB) dysfunction is associated with AD pathogenesis

• Brodmann area 39/40: regions of parietal cortex are responsible for language, spatial cognition, memory retrieval, attention, phonological processing, and emotional processing

• Hypothesis: An increased BBB permeability in Brodmann area 39/40 of AD and age-matched MCI and no cognitive impairment (NCI) subjects

 

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