Date of Presentation
5-5-2022 12:00 AM
College
School of Osteopathic Medicine
Poster Abstract
• Alzheimer’s disease (AD) is one of the most common form of dementia
• Mild cognitive impairment (MCI), specifically amnestic subtype, more likely to progress to AD
• Pathogenesis Theories:
- o Accumulation of amyloid-beta peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein
- o Blood Brain Barrier (BBB) dysfunction is associated with AD pathogenesis
• Brodmann area 39/40: regions of parietal cortex are responsible for language, spatial cognition, memory retrieval, attention, phonological processing, and emotional processing
• Hypothesis: An increased BBB permeability in Brodmann area 39/40 of AD and age-matched MCI and no cognitive impairment (NCI) subjects
Keywords
Alzheimer Disease, Dementia, Blood-Brain Barrier, Parietal Lobe, Brodmann Area 39, Neurofibrillary Tangles, tau Proteins, Amyloid beta-Peptides, Cognition
Disciplines
Medical Cell Biology | Medical Molecular Biology | Medical Neurobiology | Medicine and Health Sciences | Nervous System Diseases | Pathological Conditions, Signs and Symptoms
Document Type
Poster
Included in
Medical Cell Biology Commons, Medical Molecular Biology Commons, Medical Neurobiology Commons, Nervous System Diseases Commons, Pathological Conditions, Signs and Symptoms Commons
The Brodmann Area 39/40 of the Brain in Alzheimer’s, Mild Cognitive Impairment, and No Cognitive Impairment Subjects at Advanced Age Demonstrate Comparable Levels of Blood-Brain Barrier Breach
• Alzheimer’s disease (AD) is one of the most common form of dementia
• Mild cognitive impairment (MCI), specifically amnestic subtype, more likely to progress to AD
• Pathogenesis Theories:
- o Accumulation of amyloid-beta peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein
- o Blood Brain Barrier (BBB) dysfunction is associated with AD pathogenesis
• Brodmann area 39/40: regions of parietal cortex are responsible for language, spatial cognition, memory retrieval, attention, phonological processing, and emotional processing
• Hypothesis: An increased BBB permeability in Brodmann area 39/40 of AD and age-matched MCI and no cognitive impairment (NCI) subjects