Submitting Author(s)

Jianle Gao, Rowan University

Date of Presentation

5-4-2023 12:00 AM

College

School of Osteopathic Medicine

Poster Abstract

The correlation between the gut-microbiota- brain axis and mental state in the context of mental disorders such as Major Depressive Disorder (MDD), Schizophrenia, etc. has been well studied. Production of inflammatory and non-inflammatory metabolites by the gut- microbiota directly and indirectly affects the brain and mood. Therefore, colonization by maladaptive, pro-inflammatory bacteria may cause mood dysregulation and depressive features. Metabolites from these bacteria can be quantitatively analyzed for use as biomarkers of Major Depressive Disorder. Biomarkers studied include: serotonin, dopamine, butyrate, acetate, and propionate.

Keywords

Brain-Gut Axis, Gastrointestinal Microbiome, Mental Health, Mental Disorders, Biomarkers, Major Depressive Disorder

Disciplines

Biological Factors | Diagnosis | Health and Medical Administration | Investigative Techniques | Medicine and Health Sciences | Mental Disorders | Pathological Conditions, Signs and Symptoms | Psychiatric and Mental Health | Psychiatry

Document Type

Poster

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May 4th, 12:00 AM

Correlation Between Gut Biomarkers and Depression

The correlation between the gut-microbiota- brain axis and mental state in the context of mental disorders such as Major Depressive Disorder (MDD), Schizophrenia, etc. has been well studied. Production of inflammatory and non-inflammatory metabolites by the gut- microbiota directly and indirectly affects the brain and mood. Therefore, colonization by maladaptive, pro-inflammatory bacteria may cause mood dysregulation and depressive features. Metabolites from these bacteria can be quantitatively analyzed for use as biomarkers of Major Depressive Disorder. Biomarkers studied include: serotonin, dopamine, butyrate, acetate, and propionate.

 

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