College
Rowan-Virtua School of Osteopathic Medicine
Keywords
Brain-Gut Axis, Gastrointestinal Microbiome, Mental Health, Mental Disorders, Biomarkers, Major Depressive Disorder
Date of Presentation
5-4-2023 12:00 AM
Poster Abstract
The correlation between the gut-microbiota- brain axis and mental state in the context of mental disorders such as Major Depressive Disorder (MDD), Schizophrenia, etc. has been well studied. Production of inflammatory and non-inflammatory metabolites by the gut- microbiota directly and indirectly affects the brain and mood. Therefore, colonization by maladaptive, pro-inflammatory bacteria may cause mood dysregulation and depressive features. Metabolites from these bacteria can be quantitatively analyzed for use as biomarkers of Major Depressive Disorder. Biomarkers studied include: serotonin, dopamine, butyrate, acetate, and propionate.
Disciplines
Biological Factors | Diagnosis | Health and Medical Administration | Investigative Techniques | Medicine and Health Sciences | Mental Disorders | Pathological Conditions, Signs and Symptoms | Psychiatric and Mental Health | Psychiatry
DOI
10.31986/issn.2689-0690_rdw.stratford_research_day.135_2023
Included in
Biological Factors Commons, Diagnosis Commons, Health and Medical Administration Commons, Investigative Techniques Commons, Mental Disorders Commons, Pathological Conditions, Signs and Symptoms Commons, Psychiatric and Mental Health Commons, Psychiatry Commons
Correlation Between Gut Biomarkers and Depression
The correlation between the gut-microbiota- brain axis and mental state in the context of mental disorders such as Major Depressive Disorder (MDD), Schizophrenia, etc. has been well studied. Production of inflammatory and non-inflammatory metabolites by the gut- microbiota directly and indirectly affects the brain and mood. Therefore, colonization by maladaptive, pro-inflammatory bacteria may cause mood dysregulation and depressive features. Metabolites from these bacteria can be quantitatively analyzed for use as biomarkers of Major Depressive Disorder. Biomarkers studied include: serotonin, dopamine, butyrate, acetate, and propionate.
