Date of Presentation
5-4-2023 12:00 AM
College
School of Osteopathic Medicine
Poster Abstract
There are racial and ethnic disparities regarding pain management within the United States, and that disproportionately affects women of color. There is also a fundamental lack of information regarding the biological mechanism by which pain sensitization and perception occurs, and how it could be affected by both neurologic and somatic pain syndromes.
Methods: Research was performed on principal electronic scientific databases including Google Scholar, PubMed, and Embase with search terms “MALDI-TOF”, “ESI-MS”, “Pain”, and “Biomarkers”, as well as other modifiers to narrow the literature search.
Results: Studies on comparison between MALDI-TOF and other traditional analysis platforms, including Electrospray Ionization (ESI-MS), proteomic characterization of biomarkers related to pain, classification of disease states based on global analysis of spectrograms, disparities between racial and ethnic groups regarding pain medication prescription, workflow pipelines regarding biomarker isolation and characterization, and potential biomarkers specific to somatic and neurologic pain symptoms (Cancer, Psychiatric Sensitization, Osteoarthritis, Fibromyalgia) and general inflammation have been presented and commented on.
Conclusion: This overview supports the view that MALDI-TOF has demonstrated high utility in detecting, selecting, and characterizing biomarkers relating to pain symptoms and pain-inducing conditions, compared to more traditional methods, with greater sequence coverage during proteomic analysis, specificity, and sensitivity. Additionally, the MALDI-TOF platform can be used both clinically and experimentally to describe the biomolecular basis of disease progression. This platform can be used clinically as an objective measure of pain and pain sensation to guide clinical treatment and reduce medical care inequality for marginalized groups and individuals.
Keywords
Pain Management, Pain Perception, Somatoform Disorders, Health Disparate Populations, Women, Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry, Serum Markers
Disciplines
Bioethics and Medical Ethics | Health and Medical Administration | Health Services Administration | Investigative Techniques | Medical Biotechnology | Medicine and Health | Medicine and Health Sciences | Pathological Conditions, Signs and Symptoms | Pharmaceutical Preparations
Document Type
None
Included in
Bioethics and Medical Ethics Commons, Health and Medical Administration Commons, Health Services Administration Commons, Investigative Techniques Commons, Medical Biotechnology Commons, Medicine and Health Commons, Pathological Conditions, Signs and Symptoms Commons, Pharmaceutical Preparations Commons
MALDI-TOF MS Based Proteomic Fingerprinting of Total Serum Plasma for Somatic Pain Syndromes
There are racial and ethnic disparities regarding pain management within the United States, and that disproportionately affects women of color. There is also a fundamental lack of information regarding the biological mechanism by which pain sensitization and perception occurs, and how it could be affected by both neurologic and somatic pain syndromes.
Methods: Research was performed on principal electronic scientific databases including Google Scholar, PubMed, and Embase with search terms “MALDI-TOF”, “ESI-MS”, “Pain”, and “Biomarkers”, as well as other modifiers to narrow the literature search.
Results: Studies on comparison between MALDI-TOF and other traditional analysis platforms, including Electrospray Ionization (ESI-MS), proteomic characterization of biomarkers related to pain, classification of disease states based on global analysis of spectrograms, disparities between racial and ethnic groups regarding pain medication prescription, workflow pipelines regarding biomarker isolation and characterization, and potential biomarkers specific to somatic and neurologic pain symptoms (Cancer, Psychiatric Sensitization, Osteoarthritis, Fibromyalgia) and general inflammation have been presented and commented on.
Conclusion: This overview supports the view that MALDI-TOF has demonstrated high utility in detecting, selecting, and characterizing biomarkers relating to pain symptoms and pain-inducing conditions, compared to more traditional methods, with greater sequence coverage during proteomic analysis, specificity, and sensitivity. Additionally, the MALDI-TOF platform can be used both clinically and experimentally to describe the biomolecular basis of disease progression. This platform can be used clinically as an objective measure of pain and pain sensation to guide clinical treatment and reduce medical care inequality for marginalized groups and individuals.