Date of Presentation
5-2-2024 12:00 AM
College
Rowan-Virtua School of Osteopathic Medicine
Poster Abstract
Patients suffering from Parkinson’s Disease will typically experience a range of motor and nonmotor symptoms. Characteristic signs of Parkinson’s include pill-rolling tremor, stooped posture, and shuffling gate. Patients with this disease can also develop oropharyngeal dysfunction, which can disable patients from meeting their physiologic needs. Understanding this disability and the changes in mastication kinematics can lead to potential future treatment. Our study induced Parkinson’s in rats with rotenone injections. Their jaw kinematics were identified through fluoroscopy of radio-opaque beads implanted into different areas of their jaws. The Parkinson’s induction altered mastication significantly with an increase in anterior/posterior range of motion and a significant delay in jaw closure. The increase in range of motion was unexpected as that phenomenon is not usually seen in Parkinson’s. No other significant differences were found. Oropharyngeal dysfunction and weight loss were noted as well, indicating Parkinson’s induction. Future directions include altering treatment duration, rotenone concentration, and utilizing alternate measurements for assessing oropharyngeal dysfunction.
Keywords
Parkinson's, chewing kinematics, jaw, range of motion, oropharyngeal dysfunction, dysphagia, biomechanical phenomena, mastication, Parkinson disease
Disciplines
Disease Modeling | Medicine and Health Sciences | Musculoskeletal System | Nervous System Diseases | Pathological Conditions, Signs and Symptoms | Stomatognathic System
Document Type
Poster
DOI
10.31986/issn.2689-0690_rdw.stratford_research_day.14_2024
Included in
Disease Modeling Commons, Musculoskeletal System Commons, Nervous System Diseases Commons, Pathological Conditions, Signs and Symptoms Commons, Stomatognathic System Commons
Identifying Chewing Alterations in a Parkinsonian Model
Patients suffering from Parkinson’s Disease will typically experience a range of motor and nonmotor symptoms. Characteristic signs of Parkinson’s include pill-rolling tremor, stooped posture, and shuffling gate. Patients with this disease can also develop oropharyngeal dysfunction, which can disable patients from meeting their physiologic needs. Understanding this disability and the changes in mastication kinematics can lead to potential future treatment. Our study induced Parkinson’s in rats with rotenone injections. Their jaw kinematics were identified through fluoroscopy of radio-opaque beads implanted into different areas of their jaws. The Parkinson’s induction altered mastication significantly with an increase in anterior/posterior range of motion and a significant delay in jaw closure. The increase in range of motion was unexpected as that phenomenon is not usually seen in Parkinson’s. No other significant differences were found. Oropharyngeal dysfunction and weight loss were noted as well, indicating Parkinson’s induction. Future directions include altering treatment duration, rotenone concentration, and utilizing alternate measurements for assessing oropharyngeal dysfunction.