Date of Presentation
5-2-2024 12:00 AM
College
Rowan-Virtua School of Osteopathic Medicine
Poster Abstract
Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mechanisms remain unclear. This study aimed to investigate the effects of psychedelics on brain connectivity patterns using functional magnetic resonance imaging (fMRI). A comprehensive literature search was conducted in PubMed and Google Scholar databases using relevant keywords related to psychedelics, connectivity, therapy, and fMRI. Only studies involving major psychedelic compounds (LSD, psilocybin, ayahuasca) and measuring outcomes via fMRI were included.
The findings from the reviewed studies suggest that psychedelics induce acute disruptions in normal large-scale brain network patterns, leading to a compromised modular but enhanced global connectivity, referred to as network "disintegration" and "desegregation." This "internal" brain state correlates with aspects of the psychedelic experience, such as ego dissolution. Post-acute effects, one day after psilocybin treatment, revealed changes in cerebral blood flow and resting-state functional connectivity compared to baseline, including increased default mode network (DMN) integrity and functional connectivity within the DMN.
The proposed therapeutic mechanisms of PAP involve the synergistic combination of the psychedelic substance and the accompanying psychotherapy. Further research is warranted to delineate the specific brain connectivity changes associated with different psychedelic compounds and their relationship to therapeutic outcomes in various psychiatric conditions.
Keywords
psychedelics, Psychedelic Agents, psychedelic-assisted therapy, fMRI, Functional Magnetic Resonance Imaging, Neural Pathways, brain connectivity, brain pattern
Disciplines
Alternative and Complementary Medicine | Chemical Actions and Uses | Investigative Techniques | Medicine and Health Sciences | Psychiatric and Mental Health | Psychiatry | Psychological Phenomena and Processes
Document Type
Poster
DOI
10.31986/issn.2689-0690_rdw.stratford_research_day.179_2024
Included in
Alternative and Complementary Medicine Commons, Chemical Actions and Uses Commons, Investigative Techniques Commons, Psychiatric and Mental Health Commons, Psychiatry Commons, Psychological Phenomena and Processes Commons
Brain Connectivity Pattern Changes Associated With Psychedelic-Assisted Psychotherapy
Psychedelic-assisted psychotherapy (PAP) has shown promising therapeutic benefits for various psychiatric disorders, but the underlying neural mechanisms remain unclear. This study aimed to investigate the effects of psychedelics on brain connectivity patterns using functional magnetic resonance imaging (fMRI). A comprehensive literature search was conducted in PubMed and Google Scholar databases using relevant keywords related to psychedelics, connectivity, therapy, and fMRI. Only studies involving major psychedelic compounds (LSD, psilocybin, ayahuasca) and measuring outcomes via fMRI were included.
The findings from the reviewed studies suggest that psychedelics induce acute disruptions in normal large-scale brain network patterns, leading to a compromised modular but enhanced global connectivity, referred to as network "disintegration" and "desegregation." This "internal" brain state correlates with aspects of the psychedelic experience, such as ego dissolution. Post-acute effects, one day after psilocybin treatment, revealed changes in cerebral blood flow and resting-state functional connectivity compared to baseline, including increased default mode network (DMN) integrity and functional connectivity within the DMN.
The proposed therapeutic mechanisms of PAP involve the synergistic combination of the psychedelic substance and the accompanying psychotherapy. Further research is warranted to delineate the specific brain connectivity changes associated with different psychedelic compounds and their relationship to therapeutic outcomes in various psychiatric conditions.