College
Rowan-Virtua School of Osteopathic Medicine
Keywords
Pregnancy, PTSD, Prazosin, Post Traumatic Stress Disorder
Date of Presentation
5-1-2025 12:00 AM
Poster Abstract
Posttraumatic Stress Disorder (PTSD) affects 3–4% of pregnant and postpartum individuals and is associated with complications such as preterm birth, low birth weight, and postpartum depression. Pharmacologic treatment options during pregnancy are limited by concerns about fetal safety.
Methods: A literature review was conducted focusing on studies reporting maternal or neonatal outcomes following prazosin exposure in pregnancy.
Results: One observational study of 11 pregnancies found 54.5% had uneventful outcomes, with rates of preterm birth, miscarriage, and preeclampsia similar to the general population. Hypotension and limited lactation data remain concerns.
Conclusion: Early evidence suggests prazosin may be a relatively safe and effective adjunct for PTSD in pregnancy. Further research is needed to confirm safety and assess alternatives like Doxazosin.
Disciplines
Heterocyclic Compounds | Maternal and Child Health | Medicine and Health Sciences | Mental Disorders | Obstetrics and Gynecology | Psychiatric and Mental Health | Psychiatry | Therapeutics | Women's Health
Included in
Heterocyclic Compounds Commons, Maternal and Child Health Commons, Mental Disorders Commons, Obstetrics and Gynecology Commons, Psychiatric and Mental Health Commons, Psychiatry Commons, Therapeutics Commons, Women's Health Commons
Literature Review: Prazosin Used for PTSD in Pregnancy
Posttraumatic Stress Disorder (PTSD) affects 3–4% of pregnant and postpartum individuals and is associated with complications such as preterm birth, low birth weight, and postpartum depression. Pharmacologic treatment options during pregnancy are limited by concerns about fetal safety.
Methods: A literature review was conducted focusing on studies reporting maternal or neonatal outcomes following prazosin exposure in pregnancy.
Results: One observational study of 11 pregnancies found 54.5% had uneventful outcomes, with rates of preterm birth, miscarriage, and preeclampsia similar to the general population. Hypotension and limited lactation data remain concerns.
Conclusion: Early evidence suggests prazosin may be a relatively safe and effective adjunct for PTSD in pregnancy. Further research is needed to confirm safety and assess alternatives like Doxazosin.