Rowan Digital Works - Rowan-Virtua Research Day: Literature Review: Prazosin Used for PTSD in Pregnancy
 

College

Rowan-Virtua School of Osteopathic Medicine

Keywords

Pregnancy, PTSD, Prazosin, Post Traumatic Stress Disorder

Date of Presentation

5-1-2025 12:00 AM

Poster Abstract

Posttraumatic Stress Disorder (PTSD) affects 3–4% of pregnant and postpartum individuals and is associated with complications such as preterm birth, low birth weight, and postpartum depression. Pharmacologic treatment options during pregnancy are limited by concerns about fetal safety.

Methods: A literature review was conducted focusing on studies reporting maternal or neonatal outcomes following prazosin exposure in pregnancy.

Results: One observational study of 11 pregnancies found 54.5% had uneventful outcomes, with rates of preterm birth, miscarriage, and preeclampsia similar to the general population. Hypotension and limited lactation data remain concerns.

Conclusion: Early evidence suggests prazosin may be a relatively safe and effective adjunct for PTSD in pregnancy. Further research is needed to confirm safety and assess alternatives like Doxazosin.

Disciplines

Heterocyclic Compounds | Maternal and Child Health | Medicine and Health Sciences | Mental Disorders | Obstetrics and Gynecology | Psychiatric and Mental Health | Psychiatry | Therapeutics | Women's Health

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May 1st, 12:00 AM

Literature Review: Prazosin Used for PTSD in Pregnancy

Posttraumatic Stress Disorder (PTSD) affects 3–4% of pregnant and postpartum individuals and is associated with complications such as preterm birth, low birth weight, and postpartum depression. Pharmacologic treatment options during pregnancy are limited by concerns about fetal safety.

Methods: A literature review was conducted focusing on studies reporting maternal or neonatal outcomes following prazosin exposure in pregnancy.

Results: One observational study of 11 pregnancies found 54.5% had uneventful outcomes, with rates of preterm birth, miscarriage, and preeclampsia similar to the general population. Hypotension and limited lactation data remain concerns.

Conclusion: Early evidence suggests prazosin may be a relatively safe and effective adjunct for PTSD in pregnancy. Further research is needed to confirm safety and assess alternatives like Doxazosin.

 

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