Keywords
Diffuse Alveolar Hemorrhage, IgA Nephropathy, Vasculitis, Atypical Hemolytic Uremic Syndrome
Date of Presentation
5-1-2025 12:00 AM
Poster Abstract
IgA Nephropathy, also known as Berger disease, can precipitate acute renal failure in patients. IgA Nephropathy (IgAN) is deposition of protein from IgA into the renal tissue with subsequent renal dysfunction. IgA vasculitis (IgAV) is another condition where similarly the protein of IgA is deposited into the vessels. There are some cases of co-existing atypical hemolytic uremic syndrome (aHUS) with IgAN. However, rare combinations seen with all three IgAN, IgAV, and aHUS without any pre-existing conditions nor medical history. Patients that develop any one of these conditions are looking at life long changes with hemodialysis (HD) and organ transplants being the definitive treatment. Hemolytic Uremic Syndrome (HUS) is a multitude of thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. In this case, we focus on 27 year old male with the complement overactivation type, known as aHUS, where omplement regulatory proteins that are attacked by autoantibodies. Precipitating events or triggers are needed for dysregulation of these proteins leading to fulminant renal failure.
Disciplines
Chemical Actions and Uses | Emergency Medicine | Immune System Diseases | Medicine and Health Sciences | Nephrology | Organic Chemicals | Pathological Conditions, Signs and Symptoms
Included in
Chemical Actions and Uses Commons, Emergency Medicine Commons, Immune System Diseases Commons, Nephrology Commons, Organic Chemicals Commons, Pathological Conditions, Signs and Symptoms Commons
A Rare Case of Diffuse Alveolar Hemorrhage in the Setting of IgA Nephropathy, Vasculitis and Atypical Hemolytic Uremic Syndrome in a Previously Healthy Young Adult
IgA Nephropathy, also known as Berger disease, can precipitate acute renal failure in patients. IgA Nephropathy (IgAN) is deposition of protein from IgA into the renal tissue with subsequent renal dysfunction. IgA vasculitis (IgAV) is another condition where similarly the protein of IgA is deposited into the vessels. There are some cases of co-existing atypical hemolytic uremic syndrome (aHUS) with IgAN. However, rare combinations seen with all three IgAN, IgAV, and aHUS without any pre-existing conditions nor medical history. Patients that develop any one of these conditions are looking at life long changes with hemodialysis (HD) and organ transplants being the definitive treatment. Hemolytic Uremic Syndrome (HUS) is a multitude of thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. In this case, we focus on 27 year old male with the complement overactivation type, known as aHUS, where omplement regulatory proteins that are attacked by autoantibodies. Precipitating events or triggers are needed for dysregulation of these proteins leading to fulminant renal failure.
