College
Rowan-Virtua School of Osteopathic Medicine
Keywords
arrhythmias, celiac disease, complications, length of hospital stay
Date of Presentation
5-1-2025 12:00 AM
Poster Abstract
Background
Celiac disease has links to inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and sarcoidosis. The latter 3 also have cardiovascular manifestations associated with them. However, there are limited studies on the in-hospital outcomes of Celiac disease with cardiac manifestations. Therefore, the aim of this study was to evaluate the hospital outcomes of Celiac disease with concomitant arrhythmias.
Methods
Patients aged 18 years with Celiac disease and arrhythmias (atrial fibrillation, atrial flutter, ventricular tachycardia, and supraventricular tachycardia) versus Celiac Disease alone were identified from the US Nationwide Inpatient Sample (NIS), from the years 2019-2020. ICD 10 codes were utilized. Multivariate regression analysis was used to estimate the odds ratios of in-hospital mortality, average length of hospital stays, and hospital charges, after adjusting for age, gender, race, primary insurance payer status, hospital type and size (number of beds), hospital region, hospital teaching status, and other demographic characteristics. Weighted analysis utilizing Stata 17 MP was performed.
Results
This study identified approximately 82304 patients with Celiac Disease from the years 2019 to 2020. Of these patients, 15% had concomitant arrhythmia. Mean age of patients with Celiac disease was 56.27. The mean age of Celiac disease patients with arrhythmias was 73.79. The mean length of stay for Celiac disease patient was 4.5 days. The analysis revealed that mortality (OR 1.625, pand total hospital charges (THC) were increased ($19,504.09, pThe rate of total hospitalization death was 4%. The rate of death of Celiac disease patient with no arrhythmias was 1.42% while Celiac disease patients with arrhythmias was 3.42%.
Discussion
Celiac disease is a systemic immune-mediated disorder that is triggered by an abnormal immune response to gliadin, a component of gluten1. Hallmark inflammatory response to gluten could further augment atherosclerosis, a major contributor to cardiovascular diseases1,2. Evidence shows an increased risk of atrial fibrillation in Celiac disease patients2. Gluten free diet has also shown to notably improve arrhythmias2. However, the association of arrhythmias and Celiac disease remain understudied and further research in this area could yield better patient outcomes.
Conclusion
Our study shows that patients with Celiac disease with arrhythmias when hospitalized had increased mortality, hospital LOS, and THC. Based on our study results, patients with cardiac arrhythmias need closer monitoring and there needs to be a focus on improved treatment and management approaches through further research. Future studies should explore the impact of each type of cardiac arrhythmia on outcomes and then there can be further risk stratification based on type of cardiac arrhythmias present for Celiac disease patient.
Disciplines
Cardiology | Cardiovascular Diseases | Digestive System Diseases | Gastroenterology | Health and Medical Administration | Internal Medicine | Medicine and Health Sciences
Included in
Cardiology Commons, Cardiovascular Diseases Commons, Digestive System Diseases Commons, Gastroenterology Commons, Health and Medical Administration Commons, Internal Medicine Commons
The Presence of Cardiac Arrhythmias Impacts Hospitalized Patients With Celiac Disease
Background
Celiac disease has links to inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and sarcoidosis. The latter 3 also have cardiovascular manifestations associated with them. However, there are limited studies on the in-hospital outcomes of Celiac disease with cardiac manifestations. Therefore, the aim of this study was to evaluate the hospital outcomes of Celiac disease with concomitant arrhythmias.
Methods
Patients aged 18 years with Celiac disease and arrhythmias (atrial fibrillation, atrial flutter, ventricular tachycardia, and supraventricular tachycardia) versus Celiac Disease alone were identified from the US Nationwide Inpatient Sample (NIS), from the years 2019-2020. ICD 10 codes were utilized. Multivariate regression analysis was used to estimate the odds ratios of in-hospital mortality, average length of hospital stays, and hospital charges, after adjusting for age, gender, race, primary insurance payer status, hospital type and size (number of beds), hospital region, hospital teaching status, and other demographic characteristics. Weighted analysis utilizing Stata 17 MP was performed.
Results
This study identified approximately 82304 patients with Celiac Disease from the years 2019 to 2020. Of these patients, 15% had concomitant arrhythmia. Mean age of patients with Celiac disease was 56.27. The mean age of Celiac disease patients with arrhythmias was 73.79. The mean length of stay for Celiac disease patient was 4.5 days. The analysis revealed that mortality (OR 1.625, pand total hospital charges (THC) were increased ($19,504.09, pThe rate of total hospitalization death was 4%. The rate of death of Celiac disease patient with no arrhythmias was 1.42% while Celiac disease patients with arrhythmias was 3.42%.
Discussion
Celiac disease is a systemic immune-mediated disorder that is triggered by an abnormal immune response to gliadin, a component of gluten1. Hallmark inflammatory response to gluten could further augment atherosclerosis, a major contributor to cardiovascular diseases1,2. Evidence shows an increased risk of atrial fibrillation in Celiac disease patients2. Gluten free diet has also shown to notably improve arrhythmias2. However, the association of arrhythmias and Celiac disease remain understudied and further research in this area could yield better patient outcomes.
Conclusion
Our study shows that patients with Celiac disease with arrhythmias when hospitalized had increased mortality, hospital LOS, and THC. Based on our study results, patients with cardiac arrhythmias need closer monitoring and there needs to be a focus on improved treatment and management approaches through further research. Future studies should explore the impact of each type of cardiac arrhythmia on outcomes and then there can be further risk stratification based on type of cardiac arrhythmias present for Celiac disease patient.
