College
Rowan-Virtua School of Osteopathic Medicine
Keywords
ASD, MTHFR, mental health disorders, variants, depression, anxiety
Date of Presentation
5-1-2025 12:00 AM
Poster Abstract
• Currently little literature exists on connection between Methylenetetrahydrofolate reductase (MTHFR) deficiency and mental health disorders
• Reduced enzyme activity associated with certain MTHFR variants contributes to altered folate metabolism, elevated homocysteine levels, and disrupted DNA methylation, all of which are implicated in mental health disorders
• Identifying genetic risk factors could facilitate earlier diagnosis and intervention, leading to improved outcomes
• Relevant results could help reduce stigma and promote greater understanding of challenges faced by patients on the spectrum
Disciplines
Amino Acids, Peptides, and Proteins | Behavioral Medicine | Enzymes and Coenzymes | Medical Genetics | Medical Neurobiology | Medicine and Health Sciences | Psychiatric and Mental Health | Psychiatry
Included in
Amino Acids, Peptides, and Proteins Commons, Behavioral Medicine Commons, Enzymes and Coenzymes Commons, Medical Genetics Commons, Medical Neurobiology Commons, Psychiatric and Mental Health Commons, Psychiatry Commons
The Correlation Between a Methylenetetrahydrofolate Reductase Deficiency in Autism Spectrum Disorder Patients and The Presence of Mental Health Disorders
• Currently little literature exists on connection between Methylenetetrahydrofolate reductase (MTHFR) deficiency and mental health disorders
• Reduced enzyme activity associated with certain MTHFR variants contributes to altered folate metabolism, elevated homocysteine levels, and disrupted DNA methylation, all of which are implicated in mental health disorders
• Identifying genetic risk factors could facilitate earlier diagnosis and intervention, leading to improved outcomes
• Relevant results could help reduce stigma and promote greater understanding of challenges faced by patients on the spectrum
