College
Rowan-Virtua School of Osteopathic Medicine
Keywords
dopamine D4 receptor, Open field test, locomotor activity, anxiety-like behavior
IRB or IACUC Protocol Number
TBIPHRP-IIRA: W81XWH-22-1-0616 and W81XWH-22-1-0618
Date of Presentation
5-1-2025 12:00 AM
Poster Abstract
The consequences of modulating subtypes of G protein coupled dopamine receptors are broadly studied for their role in decision making behavior, specifically in situations involving uncertain risk and reward. The actions of dopamine D4 receptors (D4Rs) on these complex processes are the least understood, particularly due to a lack of available compounds with suitable selectivity for D4Rs. Further, current research often fails to evaluate how modulating specific dopamine receptor subtypes may affect locomotor activity and anxiety-like behavior as confounding factors prior to assessing their function in behavioral assays of higher order decision making. The goal of the current study was to evaluate the extent that D4R modulation contributes to locomotor and anxiety-like behavioral measures and serve as potential confounding variables when evaluated in future experiments that will assay more complex risk/reward decision making behaviors. As such, the current report utilized the open-field test to assess the effects of novel and selective D4 receptor targeted compounds; a full antagonist (FMJ-054), a high-efficacy partial agonist (FMJ-038), and a low-efficacy partial agonist (FMJ-045) on locomotor activity and anxiety-like behavior in male and female Sprague Dawley rats.
Disciplines
Animal Experimentation and Research | Behavior and Behavior Mechanisms | Medicine and Health Sciences | Neuroscience and Neurobiology | Organic Chemicals
Included in
Animal Experimentation and Research Commons, Behavior and Behavior Mechanisms Commons, Neuroscience and Neurobiology Commons, Organic Chemicals Commons
Effects of Novel Dopamine D4 Receptor-Targeted Compounds on locomotor activity and Anxiety-Like Behavior in Male and Female Sprague Dawley Rats
The consequences of modulating subtypes of G protein coupled dopamine receptors are broadly studied for their role in decision making behavior, specifically in situations involving uncertain risk and reward. The actions of dopamine D4 receptors (D4Rs) on these complex processes are the least understood, particularly due to a lack of available compounds with suitable selectivity for D4Rs. Further, current research often fails to evaluate how modulating specific dopamine receptor subtypes may affect locomotor activity and anxiety-like behavior as confounding factors prior to assessing their function in behavioral assays of higher order decision making. The goal of the current study was to evaluate the extent that D4R modulation contributes to locomotor and anxiety-like behavioral measures and serve as potential confounding variables when evaluated in future experiments that will assay more complex risk/reward decision making behaviors. As such, the current report utilized the open-field test to assess the effects of novel and selective D4 receptor targeted compounds; a full antagonist (FMJ-054), a high-efficacy partial agonist (FMJ-038), and a low-efficacy partial agonist (FMJ-045) on locomotor activity and anxiety-like behavior in male and female Sprague Dawley rats.
