Faculty mentor/PI email address
Yschneid@virtua.org
Is your research Teaching and Learning based?
1
Keywords
CKD, ESRD, ERCP, Endoscopy, Renal Failure, Mortality
Date of Presentation
5-6-2026 12:00 AM
Poster Abstract
Background: Chronic kidney disease (CKD) is known to influence clinical outcomes across a range of procedures, but its impact on endoscopic retrograde cholangiopancreatography (ERCP) outcomes remains poorly characterized. We evaluated the association between CKD and post-ERCP survival and procedural complications.
Methods: A retrospective cohort study was conducted using the TriNetX database. Adults with CKD stages 1–5 undergoing ERCP between 2010–2024 were identified and compared to patients without CKD undergoing the same procedure. Propensity score matching (1:1) was performed to balance known demographic and clinical confounders. Primary outcomes included 30-day all-cause mortality, procedural complications, all-cause infections, and gastrointestinal bleeding. Adjusted hazard ratios (HR) with 95% confidence intervals were estimated.
Results: Following propensity score matching, CKD patients undergoing ERCP demonstrated significantly higher 30-day mortality compared with non-CKD patients (HR 1.57, 95% CI 1.46–1.68, p< 0.0001). CKD was also associated with increased risks of procedural complications (HR 1.11, 95% CI 1.07–1.16, p< 0.0001), all-cause infections (HR 1.08, 95% CI 1.06–1.11, p=0.007), and gastrointestinal bleeding (HR 1.15, 95% CI 1.09–1.21, p< 0.0001). These findings were consistent across CKD stages after adjustment for confounders.
Conclusions: CKD significantly increases the risk of short-term mortality, procedural complications, infections, and gastrointestinal bleeding following ERCP. These findings highlight the need for heightened periprocedural risk stratification and monitoring in CKD patients undergoing ERCP and may inform informed consent discussions and post-procedure management protocols.
Disciplines
Endocrine System Diseases | Medicine and Health Sciences | Nutritional and Metabolic Diseases
IMPACT OF CHRONIC KIDNEY DISEASE ON OUTCOMES FOLLOWING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP): A PROPENSITY-MATCHED COHORT STUDY USING THE TRINETX DATABASE
Background: Chronic kidney disease (CKD) is known to influence clinical outcomes across a range of procedures, but its impact on endoscopic retrograde cholangiopancreatography (ERCP) outcomes remains poorly characterized. We evaluated the association between CKD and post-ERCP survival and procedural complications.
Methods: A retrospective cohort study was conducted using the TriNetX database. Adults with CKD stages 1–5 undergoing ERCP between 2010–2024 were identified and compared to patients without CKD undergoing the same procedure. Propensity score matching (1:1) was performed to balance known demographic and clinical confounders. Primary outcomes included 30-day all-cause mortality, procedural complications, all-cause infections, and gastrointestinal bleeding. Adjusted hazard ratios (HR) with 95% confidence intervals were estimated.
Results: Following propensity score matching, CKD patients undergoing ERCP demonstrated significantly higher 30-day mortality compared with non-CKD patients (HR 1.57, 95% CI 1.46–1.68, p< 0.0001). CKD was also associated with increased risks of procedural complications (HR 1.11, 95% CI 1.07–1.16, p< 0.0001), all-cause infections (HR 1.08, 95% CI 1.06–1.11, p=0.007), and gastrointestinal bleeding (HR 1.15, 95% CI 1.09–1.21, p< 0.0001). These findings were consistent across CKD stages after adjustment for confounders.
Conclusions: CKD significantly increases the risk of short-term mortality, procedural complications, infections, and gastrointestinal bleeding following ERCP. These findings highlight the need for heightened periprocedural risk stratification and monitoring in CKD patients undergoing ERCP and may inform informed consent discussions and post-procedure management protocols.