Faculty mentor/PI email address
Christopher.Snyder@jefferson.edu
Keywords
Immunology, Cell biology, periprosthetic joint infections, total joint replacement, synovial fluid, macrophages
Date of Presentation
5-6-2026 12:00 AM
Poster Abstract
Periprosthetic joint infections (PJI) are devastating complications of total joint replacement (TJA). Even with aggressive antibiotic treatments, PJI recurrence rates are >17%, and 5-year survival is only 87.3%. Understanding the levels of inflammatory markers and cell types present at different timepoints is crucial in maximizing antimicrobial therapy and preventing adverse outcomes following TJA. This study tests the hypothesis that the synovial fluid environment of PJI induces immunosuppression in human macrophages, thereby hindering their ability to kill bacteria.
Disciplines
Bacterial Infections and Mycoses | Medicine and Health Sciences | Musculoskeletal Diseases
Understanding the Immune Responses of Macrophages and Neutrophils in Synovial Fluid and Post-Operative Joint Environments
Periprosthetic joint infections (PJI) are devastating complications of total joint replacement (TJA). Even with aggressive antibiotic treatments, PJI recurrence rates are >17%, and 5-year survival is only 87.3%. Understanding the levels of inflammatory markers and cell types present at different timepoints is crucial in maximizing antimicrobial therapy and preventing adverse outcomes following TJA. This study tests the hypothesis that the synovial fluid environment of PJI induces immunosuppression in human macrophages, thereby hindering their ability to kill bacteria.