Document Type
Article
Version Deposited
Published Version
Publication Date
1-10-2015
Publication Title
Scientific Reports
DOI
10.1038/srep12842
Abstract
Visualizing the movement of angiocatheters during endovascular interventions is typically accomplished using x-ray fluoroscopy. There are many potential advantages to developing magnetic resonance imaging-based approaches that will allow three-dimensional imaging of the tissue/vasculature interface while monitoring other physiologically-relevant criteria, without exposing the patient or clinician team to ionizing radiation. Here we introduce a proof-of-concept development of a magnetic resonance imaging-guided catheter tracking method that utilizes hyperpolarized silicon particles. The increased signal of the silicon particles is generated via low-temperature, solid-state dynamic nuclear polarization, and the particles retain their enhanced signal for ≥40 minutes—allowing imaging experiments over extended time durations. The particles are affixed to the tip of standard medical-grade catheters and are used to track passage under set distal and temporal points in phantoms and live mouse models. With continued development, this method has the potential to supplement x-ray fluoroscopy and other MRI-guided catheter tracking methods as a zero-background, positive contrast agent that does not require ionizing radiation.
Recommended Citation
Whiting, N., Hu, J., Shah, J. V., Cassidy, M. C., Cressman, E., Millward, N. Z., ... Bhattacharya, P. K. (2015). Real-Time MRI-Guided Catheter Tracking Using Hyperpolarized Silicon Particles. Scientific Reports, 5, [12842]. DOI: 10.1038/srep12842.
Comments
Scientific Reports is a peer-reviewed Open Access journal included in the Directory of Open Access Journals (DOAJ).