Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer

Authors

Nicholas Whiting, Rowan University
Jingzhe Hu, University of Texas MD Anderson Cancer Center
Niki Zacharias, University of Texas MD Anderson Cancer Center
Ganesh Lokesh, University of Texas Health Science Center at Houston
David Volk, University of Texas Health Science Center at Houston
David Menter, University of Texas MD Anderson Cancer Center
Rajesha Rupaimoole, University of Texas MD Anderson Cancer Center
Rebecca Previs, University of Texas MD Anderson Cancer Center
Anil Sood, University of Texas MD Anderson Cancer Center
Pratip Bhattacharya, University of Texas MD Anderson Cancer Center

Document Type

Article

Version Deposited

Published Version

Publication Date

8-10-2016

Publication Title

Journal of medical imaging

DOI

10.1117/1.JMI.3.3.036001

Abstract

Silicon-based nanoparticles are ideally suited for use as biomedical imaging agents due to their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization, which increases magnetic resonance imaging signals by several orders-of-magnitude through enhanced nuclear spin alignment, has recently been developed to allow silicon particles to function as contrast agents for in vivo magnetic resonance imaging. The enhanced spin polarization of silicon lasts significantly longer than other hyperpolarized agents (tens of minutes, whereas

Comments

Journal of Medical Imaging is a RoMEO green journal: the author can archive the publisher's version.

Recommended Citation

Whiting, N., Hu, J., Zacharias, N. M., Ganesh, L. R., Lokesh, D. E., Volk, D. G., ... & Bhattacharya, P. (2016). Developing hyperpolarized silicon particles for in vivo MRI targeting of ovarian cancer. Journal of Medical Imaging 3(3), 036001.