Document Type
Article
Version Deposited
Published Version
Publication Date
8-1-2013
Publication Title
G3: Genes, Genomes, Genetics
DOI
http://dx.doi.org/10.1534/g3.113.006585
Abstract
The genome of budding yeast (Saccharomyces cerevisiae) contains approximately 5800 protein-encoding genes, the majority of which are associated with some known biological function. Yet the extent of amino acid sequence conservation of these genes over all phyla has only been partially examined. Here we provide a more comprehensive overview and visualization of the conservation of yeast genes and a means for browsing and exploring the data in detail, down to the individual yeast gene, at http://yeast-phylogroups.princeton.edu. We used data from the OrthoMCL database, which has defined orthologs from approximately 150 completely sequenced genomes, including diverse representatives of the archeal, bacterial, and eukaryotic domains. By clustering genes based on similar patterns of conservation, we organized and visualized all the protein-encoding genes in yeast as a single heat map. Most genes fall into one of eight major clusters, called “phylogroups.” Gene ontology analysis of the phylogroups revealed that they were associated with specific, distinct trends in gene function, generalizations likely to be of interest to a wide range of biologists.
Recommended Citation
Gibney, P. A., Hickman, M. J., Bradley, P. H., Matese, J. C., & Botstein, D. (2013). Phylogenetic portrait of the saccharomyces cerevisiae functional genome. G3 (Bethesda, Md.), 3(8), 1335-1340.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
