Document Type
Article
Version Deposited
Published Version
Publication Date
1-19-2021
Publication Title
Molecules
DOI
10.3390/molecules26020514
Abstract
In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there is a pressing need to understand the structure and function of proteins in novel environments with ILs. Understanding the short-term and long-term stability of protein molecules in IL formulations will be key to using ILs for protein technologies. Similarly, ILs have been investigated as part of therapeutic delivery systems and implicated in numerous studies in which ILs impact the activity and/or stability of protein molecules. Notably, many of the proteins used in industrial applications are involved in redox chemistry, and thus often contain metal ions or metal-associated cofactors. In this review article, we focus on the current understanding of protein structure-function relationship in the presence of ILs, specifically focusing on the effect of ILs on metal containing proteins.
Recommended Citation
Patel, Aashka Y., Keertana S. Jonnalagadda, Nicholas Paradis, Timothy D. Vaden, Chun Wu, and Gregory A. Caputo 2021. "Effects of Ionic Liquids on Metalloproteins" Molecules 26, no. 2: 514. https://doi.org/10.3390/molecules26020514
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.