Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

Authors

William C. Neuhaus
Ian J. Bakanas
Joseph R. Lizza
Charles T. Boon Jr.
Gustavo Moura-Letts, Rowan UniversityFollow

Document Type

Article

Version Deposited

Published Version

Publication Date

3-9-2016

Publication Title

Green Chemistry Letters and Reviews

DOI

http://dx.doi.org/10.1080/17518253.2016.1149231

Abstract

Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

Comments

© 2016 The Author(s). Published by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Recommended Citation

Neuhaus, W. C., Bakanas, I. J., Lizza, J. R., Boon, C. T., & Moura-Letts, G. (2016). Novel biodegradable protonic ionic liquid for the fischer indole synthesis reaction. Green Chemistry Letters and Reviews, 9(1), 39-43.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.