Document Type
Review
Version Deposited
Published Version
Publication Date
6-21-2024
Publication Title
Heliyon
DOI
10.1016/j.heliyon.2024.e33091
Abstract
Multiple Myeloma (MM) is a malignant expansion of plasma cells in the bone marrow (BM), resulting in a disease characterized by symptoms of end organ damage from light chain secretion, crowding of the BM, and bone lesions. Although the past two decades have been characterized by numerous novel therapies emerging, the disease remains incurable due to intrinsic or acquired drug resistance. A major player in MM's drug resistance arises from its intimate relationship with the BM microenvironment (BMME). Through stress-inducing conditions, soluble messengers, and physical adhesion to BM elements, the BMME activates numerous pathways in the myeloma cell. This not only propagates myeloma progression through survival and growth signals, but also specific mechanisms to circumvent therapeutic actions. In this review, we provide an overview of the BMME, the role of individual components in MM survival, and various therapy-specific resistance mechanisms reported in the literature.
Recommended Citation
Bhowmick, K., von Suskil, M., Al-Odat, O. S., Elbezanti, W. O., Jonnalagadda, S. C., Budak-Alpdogan, T., & Pandey, M. K. (2024). Pathways to therapy resistance: The sheltering effect of the bone marrow microenvironment to multiple myeloma cells. Heliyon, 10(12), e33091. 10.1016/j.heliyon.2024.e33091
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Comments
© 2024 The Authors, Published by Elsevier Ltd.