Document Type
Article
Version Deposited
Published Version
Open Access Funding Source
Open Access Publishing Fund
Publication Date
11-17-2022
Publication Title
Frontiers in Bioengineering and Biotechnology
DOI
10.3389/fbioe.2022.1047851
Abstract
Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes. We demonstrate a µsPEF bioeffect on nucleocytoplasmic import and export of enzymes that regulate genetic expression, histone deacetylases (HDAC) -4 and -5. Their μsPEF-induced nucleocytoplasmic transport depends on presence and absence of extracellular calcium ions (Ca
Recommended Citation
Safaei Z, Thompson GL. Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity. Front Bioeng Biotechnol. 2022 Nov 17;10:1047851. doi: 10.3389/fbioe.2022.1047851.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
Copyright © 2022 Safaei and Thompson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Publication of this article was supported by the 2022-23 Rowan University Libraries Open Access Publishing Fund.