Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity.

Authors

Zahra Safaei
Gary L. Thompson III, Rowan UniversityFollow

Document Type

Article

Version Deposited

Published Version

Publication Date

11-17-2022

Publication Title

Frontiers in Bioengineering and Biotechnology

DOI

10.3389/fbioe.2022.1047851

Abstract

Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes. We demonstrate a µsPEF bioeffect on nucleocytoplasmic import and export of enzymes that regulate genetic expression, histone deacetylases (HDAC) -4 and -5. Their μsPEF-induced nucleocytoplasmic transport depends on presence and absence of extracellular calcium ions (Ca

Comments

Copyright © 2022 Safaei and Thompson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Publication of this article was supported by the 2022-23 Rowan University Libraries Open Access Publishing Fund.

Recommended Citation

Safaei Z, Thompson GL. Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity. Front Bioeng Biotechnol. 2022 Nov 17;10:1047851. doi: 10.3389/fbioe.2022.1047851.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.