Document Type
Article
Version Deposited
Published Version
Publication Date
12-2023
Publication Title
Advanced Materials Interfaces
DOI
10.1002/admi.202300492
Abstract
Separation and identification of molecules and biomolecules such as nucleic acids, proteins, and polysaccharides from complex fluids are known to be important due to unmet needs in various applications. Generally, many different separation techniques, including chromatography, electrophoresis, and magnetophoresis, have been developed to identify the target molecules precisely. However, these techniques are expensive and time consuming. “Lab-on-a-chip” systems with low cost per device, quick analysis capabilities, and minimal sample consumption seem to be ideal candidates for separating particles, cells, blood samples, and molecules. From this perspective, different microfluidic-based techniques have been extensively developed in the past two decades to separate samples with different origins. In this review, “lab-on-a-chip” methods by passive, active, and hybrid approaches for the separation of biomolecules developed in the past decade are comprehensively discussed. Due to the wide variety in the field, it will be impossible to cover every facet of the subject. Therefore, this review paper covers passive and active methods generally used for biomolecule separation. Then, an investigation of the combined sophisticated methods is highlighted. The spotlight also will be shined on the elegance of separation successes in recent years, and the remainder of the article explores how these permit the development of novel techniques.
Recommended Citation
A. Ebrahimi, K. Icoz, R. Didarian, C.-H. Shih, E. A. Tarim, B. Nasseri, A. Akpek, B. Cecen, A. Bal-Ozturk, K. Güleç, Y.-C. E. Li, S. Shih, B. Sirma Tarim, H. C. Tekin, E. Alarçin, M. Tayybi-Azar, H. Ghorbanpoor, C. Özel, A. Eker Sarıboyacı, F. Dogan Guzel, N. Bassous, S. R. Shin, H. Avci, Molecular Separation by Using Active and Passive Microfluidic chip Designs: A Comprehensive Review. Adv. Mater. Interfaces 2024, 11, 2300492. https://doi.org/10.1002/admi.202300492
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Comments
©2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License,