Effects of passive and active training paradigms on bone and muscle recovery after spinal cord injury
MS Mechanical Engineering
Henry M. Rowan College of Engineering
New Jersey Commission on Spinal Cord Exploratory Research
Committee Member 1
Committee Member 2
Bone Degeneration, Bone Recovery, Muscle Atrophy, Muscle Recovery, Spinal Cord Injury, Training
Spinal cord--Wounds and injuries--Rehabilitation
Biomedical Engineering and Bioengineering | Mechanical Engineering
The effects spinal cord injury (SCI) has have been studied in both human and animal models. Specifically in incomplete SCI, the bone degradation and muscle atrophy seen in the lower limbs has been documented, along with the effects of different training paradigms on bone and muscle loss. This study implemented a clinically relevant animal model of a moderate spinal contusion injury at the T9--T10 level, along with active body weight supported treadmill training (BWSTT) and passive bike training, to compare the effects such training methods have on the bone microstructure properties and muscle masses in the lower limbs of rats. Behavioral BBB and wire grid testing, along with three-point bending, was conducted. Our results showed that both passive and active trained animals did not show any significant differences from normal animals in metaphyseal region bone volume over total volume (BV/TV), and bike trained animals had no significant differences in trabecular separation (Tb.Sp) from normal animals. Further comparisons were drawn from the remaining properties of trabecular thickness (Tb.Th), trabecular number (Tb.N), and soleus muscle masses. This study allows for a comprehensive view of bone recovery on SCI with active and passive training paradigms.
King, Brittany Lynn, "Effects of passive and active training paradigms on bone and muscle recovery after spinal cord injury" (2017). Theses and Dissertations. 2440.