Date Approved
5-1-2018
Embargo Period
5-2-2018
Document Type
Thesis
Degree Name
MS Pharmaceutical Sciences
Department
Chemistry and Biochemistry
College
College of Science & Mathematics
Advisor
Jonnalagadda, Subash
Committee Member 1
Ramanujachary, Kandalam
Committee Member 2
Wu, Chun
Keywords
Passerini reaction, azaheterocyclic compounds, multicomponent coupling reactions, anti-cancer agents, synthesis, green chemistry
Subject(s)
Pharmaceutical chemistry; Organic compounds--Synthesis
Disciplines
Medicinal and Pharmaceutical Chemistry | Pharmacy and Pharmaceutical Sciences
Abstract
Multicomponent coupling reactions (MCRs) have been known for a long time and one such reaction that utilizes isocyanides is Passerini reaction. It is a powerful tool to synthesize libraries of different compounds. Azaheterocyclic compounds play an important role in medicinal chemistry. Motifs such as imidazoles, piperazines, pyrazoles, pyridines, triazoles, etc. are routinely observed in several compounds of pharmacological interest. Several natural products also contain these motifs in them. We have undertaken a library synthesis of heterocyclic molecules driven by our group's long-standing interest of synthesizing medicinally relevant small molecules employing green chemistry techniques.
This thesis details our efforts on the development of novel synthetic methodologies for the synthesis of functionalized azaheterocyclic compounds as potential anti-cancer agents. We initiated the synthesis of these compounds employing Passerini reaction as the key step. The biological evaluation of these synthetic derivatives showed some promise as anti-cancer agents.
Recommended Citation
Pandya, Keyur M., "Synthesis and cytotoxicity of azaheterocyclic compounds" (2018). Theses and Dissertations. 2549.
https://rdw.rowan.edu/etd/2549
