Date Approved

9-24-2018

Embargo Period

9-25-2018

Document Type

Thesis

Degree Name

MS Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Moura-Letts, Gustavo

Committee Member 1

Jonnalagadda, Subash

Committee Member 2

Grinias, James

Keywords

drug scaffolds, titanium dioxide, Hydroxylamine-O-Sulfonic Acid (HOSA), heterocyclic compounds, synthesis of amino acids

Subject(s)

Drug development; Green chemistry

Disciplines

Medicinal-Pharmaceutical Chemistry

Abstract

With the introductions of pharmaceuticals into modern day society many people have been using them to improve their lives. Due to this high increase in demand along with the ever-growing concern of environmental impact pharmaceutical companies have been pressed to synthesis new and existing drugs at a higher rate. This increased rate can cause low yield drugs or have a heavy environmental impact. As the use of pharmaceuticals becomes more widespread the need for greener and simpler organic synthesis methods to make these pharmaceuticals becomes more needed.

Herein is reported the methodological development of different pharmacologically relevant scaffolds. This work shows Titanium Dioxide (TiO2, rutile) as well as Hydroxylamine-O-Sulfonic Acid (HOSA) can be employed to make a scaffold that is commonly used for the synthesis of amino acids. This work also presents two methods for the formation of heterocyclic compounds that have been found to have antibacterial properties. These works highlight the value of simple methodology to achieve relevant scaffolds for pharmaceuticals.

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