Date Approved

4-6-2021

Embargo Period

4-7-2021

Document Type

Thesis

Degree Name

M.S. Mechanical Engineering

Department

Mechanical Engineering

College

Henry M. Rowan College of Engineering

First Advisor

Miri, Amir K.

Second Advisor

Osta, Anu Ranjan

Third Advisor

Trkov, Mitja

Keywords

3D Bioprinting, ANSYS Fluent, Bioinks, Computational Fluid Dynamics, Numerical modeling

Subject(s)

Computational fluid dynamics; Three-dimensional printing

Disciplines

Mechanical Engineering

Abstract

Extrusion bioprinting involves the deposition of bioinks in a layer-wise fashion to build 3D structures that mimic natural living systems' behavior in tissue engineering. Hydrogels are the most common bioinks, in which their viscosity properties are dependent on the shear-rate, such as Non-Newtonian fluids. Numerical simulation of extrusion bioprinting may help study the flow properties of hydrogels and designing improved bioinks. In this thesis, the instability caused by the shear-thinning or -thickening parameter during extrusion is numerically compared with the theoretical estimations. The process of fiber deposition of hydrogels onto a substrate through the single and coaxial nozzle is done using a commercial package (ANSYS Fluent). For various power-law bioinks, the morphology of single and multi-layer 3D bioprinted fibers, including the velocity, printing pressure, wall shear stress, and mixing proportion of two bioinks during bioprinting, are predicted for the first time.

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