M.S. Mechanical Engineering
Henry M. Rowan College of Engineering
Miri, Amir K.
Osta, Anu Ranjan
3D Bioprinting, ANSYS Fluent, Bioinks, Computational Fluid Dynamics, Numerical modeling
Computational fluid dynamics; Three-dimensional printing
Extrusion bioprinting involves the deposition of bioinks in a layer-wise fashion to build 3D structures that mimic natural living systems' behavior in tissue engineering. Hydrogels are the most common bioinks, in which their viscosity properties are dependent on the shear-rate, such as Non-Newtonian fluids. Numerical simulation of extrusion bioprinting may help study the flow properties of hydrogels and designing improved bioinks. In this thesis, the instability caused by the shear-thinning or -thickening parameter during extrusion is numerically compared with the theoretical estimations. The process of fiber deposition of hydrogels onto a substrate through the single and coaxial nozzle is done using a commercial package (ANSYS Fluent). For various power-law bioinks, the morphology of single and multi-layer 3D bioprinted fibers, including the velocity, printing pressure, wall shear stress, and mixing proportion of two bioinks during bioprinting, are predicted for the first time.
Talluri, Dhanvanth Jaya, "Numerical modeling of the fiber deposition flow in extrusion-based 3D bioprinting" (2021). Theses and Dissertations. 2877.