Date Approved

8-9-2021

Embargo Period

8-10-2021

Document Type

Thesis

Degree Name

M.S. Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Gustavo Moura-Letts, Ph.D.

Committee Member 1

James Grinias, Ph.D.

Committee Member 2

Subash Jonnalagadda, Ph.D.

Keywords

Vinyl Oxaziridines, Aromatic Bromides, Aromatic Fluorides, pharmaceutical compounds, chemical synthesis

Subject(s)

Drugs--Design; Organic photochemistry

Disciplines

Medicinal and Pharmaceutical Chemistry

Abstract

Visible light has become a highly useful, and regarded, tool to the organic chemist. The additions and transformations of an abundance of molecules can be achieved with the use of visible light and photocatalysts, when appropriate. More specifically compounds that contain nitrogen, halogens, or both are highly useful structures in nearly every chemical industry. They are elements found in naturally occurring molecules and have the capacity to mimic biologically active and relevant structures. This makes them useful targets for pharmaceutical compounds. Bromine and chlorine can act as leaving groups; this property makes molecules with these elements reactive and thus able produce desirable effects in vivo. Nitrogen can be found within and outside of cyclic structures and is one of the most commonly functionalized elements in pharmaceuticals. The element can be found in nearly every class of pharmaceuticals ranging from chemotherapeutic to antifungal agents. Herein is reported the methodological development of synthetic nitrogen and halogen placement through a wide variety of chemical moieties. This work shows that visible light and photocatalysts can be used to furnish small heteroatomic compounds and halogenated products. These works highlight the value of substituted hydroxylamines for their nitrogen transfer capability; metal-halogen compounds in visible light transformations will also be highlighted.

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