Date Approved

6-28-2024

Embargo Period

7-1-2024

Document Type

Thesis

Degree Name

Master of Science (M.S.) in Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Subash Jonnalagadda, Ph.D.

Committee Member 1

Manoj Pandey, Ph.D.

Committee Member 2

Kandalam Ramanujachary, Ph.D.

Keywords

triple negative breast cancer, Salinomycin

Subject(s)

Cancer--Treatment

Disciplines

Chemistry | Medicinal-Pharmaceutical Chemistry

Abstract

Triple negative breast cancer (TNBC) is a more aggressive type of breast cancer which contains faster growth, higher metastasis rate and worse prognosis. The main challenge toward treatment of this type of cancer is being heterogeneous. Recently, Salinomycin (SAL) has been considered as a potential agent for triple negative breast cancer treatment. However, chemical modification of SAL is needed to improve SAL selectivity to cations and decrease its cytotoxicity. The purpose of this study was to evaluate the effect of chemically modified analogs of SAL on the viability, metastasis, Wnt pathway as well as angiogenesis of Triple negative breast cancer (TNBC) cell lines using MTT assay, Western blot and Invasion assay. Obtained results indicated that the tested compounds may have the potential to inhibit angiogenesis, metastasis and alter Wnt signaling pathway. However, more studies are needed to clarify their effects on CSCs, in vivo and moreover, the effects on both tumor and normal cells.

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