Date Approved
6-2-2025
Embargo Period
6-2-2026
Document Type
Thesis
Degree Name
M.S. Chemical Engineering
Department
Chemical Engineering
College
College of Education
Advisor
Gerard Capellades, Ph.D.
Committee Member 1
Robert Hesketh, Ph.D.
Committee Member 2
Kirti Yenkie, Ph.D.
Keywords
Crystallization;Kinetics;MSMPR;Process Analytical Technologies (PATs);Solvent Effects
Disciplines
Chemical Engineering | Engineering
Abstract
The use of crystallization for separation is not a recent phenomenon. However, the development of efficient crystallization processes is continually being challenged by the complexity and high cost of new drug substances, coupled with stringent regulatory requirements, which add to the uncertainty surrounding drug launches by pharmaceutical enterprises. Accurate characterization of crystallization kinetics is a key step in crystallizer design, which can be influenced by several factors, including process conditions, scale, and the measurement techniques used for tracking particle evolution. These factors often lead to inconsistencies between kinetic studies, hindering rapid implementation within industrial contexts. This thesis presents a case study on crystallization kinetics, focusing on how solvent dependency of nucleation and growth parameters are influenced by process and operating modes. Nucleation and growth parameters were estimated using semi empirical kinetics models coupled to population balance equations for a selected pharmaceutical ingredient in a binary solvent mixture at 5 mL solute-solvent suspension volume. This was followed by a scale-up study using a continuous antisolvent crystallization at 300 mL volume. The study provides an approach for characterizing crystallization kinetics under scale-down conditions via kinetics trends, minimizing time and resource demands during process development, while highlighting differences between crystallization methods and process analytical technologies (PAT).
Recommended Citation
Joel, Ibrahim, "INVESTIGATING SOLVENT EFFECTS ON CRYSTALLIZATION KINETICS" (2025). Theses and Dissertations. 3374.
https://rdw.rowan.edu/etd/3374
