Date Approved

7-14-2025

Embargo Period

7-14-2025

Document Type

Thesis

Degree Name

M.S. Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Ping Lu, Ph.D.

Committee Member 1

Yu Lei, Ph.D.

Committee Member 2

Zhihong Wang, Ph.D.

Abstract

In this study, core-shell microparticles were synthesized using coaxial electrospray techniques, with Zeolitic Imidazolate Framework-8 encapsulating either Rhodamine B or Doxorubicin in the core. ZIF-8 is a material well regarded for its effectiveness in drug delivery systems. Phase change materials are composed of a 4:1 mixture of lauric acid and stearic acid in the shell. The PCM chosen has a melting point close to physiological body temperature. The structural morphology and thermal stability of the microparticles were confirmed using Scanning Electron Microscopy, X-ray Diffraction, Differential Scanning Calorimetry, Thermogravimetric Analysis, and Infrared Spectroscopy. The release of the drug was influenced by both pH and temperature; a dual stimulus-controlled release for the drug was observed, with release rates increasing by 27% at pH 7.4 and 41% at pH 4.0, under the same temperature change. These results demonstrate the capability of the coaxial electrospray system to facilitate targeted and controlled drug release, potentially improving therapeutic outcomes in the treatment of solid tumors by reducing side effects and enhancing patient compliance and effectiveness.

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