Date Approved
8-25-2025
Embargo Period
8-25-2025
Document Type
Thesis
Degree Name
M.S. Pharmaceutical Sciences
Department
Pharmaceutical Sciences
College
College of Science & Mathematics
Advisor
Amos Mugweru, Ph.D.
Committee Member 1
James Grinias, Ph.D.
Committee Member 2
Subash Jonnalagadda, Ph.D.
Abstract
Artemisinin and derivatives were subjected to 37°C and room temperature conditions. When HPLC-UV analysis of both conditions was performed, there were differences in both conditions which suggested that artemisinin and derivatives degrade at 37°C. When artemisinin was electrochemically reduced, new peaks were generated and LC-MS analysis of the reduced artemisinin indicated that either new molecules or molecular reorganization was formed. These electrochemical reduction molecules (products) were deemed analogous to the artemisinin reduction occurring in-vivo after oral administration. Fluorescence analysis of artemisinin and derivatives were performed in the presence of dipyridamole. Dipyridamole intensity was observed to decrease when artemisinin or its derivatives was mixed with hemin in the presence of dipyridamole. This suggested production of Reactive Oxygen Species (ROS) quenching dipyridamole.
Recommended Citation
Ombwayo, Faraja, "ANALYTICAL CHARACTERIZATION OF ARTEMISININ AND ITS DERIVATIVES USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY, ELECTROCHEMISTRY REDUCTION, AND FLUORESCENCE" (2025). Theses and Dissertations. 3442.
https://rdw.rowan.edu/etd/3442
