Document Type

Article

Version Deposited

Published Version

Publication Date

1-1-2024

Publication Title

Case Rep Psychiatry

DOI

10.1155/crps/6452923

Abstract

Nightmares and flashbacks are common debilitating symptoms of posttraumatic stress disorder (PTSD) that can disrupt daily functioning. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of these intrusion symptoms, although its short half-life makes it so that often multiple doses are needed. Doxazosin, another alpha-1 antagonist, is starting to be investigated in the treatment of PTSD-related nightmares due to its lesser side effect profile and longer half-life. In our case series, we present three cases of patients with PTSD-related nightmares who were successfully treated with doxazosin following a relapse of symptoms after discontinuation of prazosin for various reasons. The success of doxazosin immediate release for PTSD-related nightmares warrants further studies into its efficacy and use as an alternative treatment to prazosin.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Published Citation

Khan, Danyaal, Richardson, Christie, Forsberg, Martin, Doxazosin Immediate Release as a Novel Treatment for Nightmares in Posttraumatic Stress Disorder, Case Reports in Psychiatry, 2024, 6452923, 4 pages, 2024. https://doi.org/10.1155/crps/6452923

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