Date of Presentation
5-5-2022 12:00 AM
College
School of Osteopathic Medicine
Poster Abstract
• The ketogenic diet is a popular, controversial diet that fuels the brain through beta-oxidation of fatty acids and production of ketone bodies, the most populous of which is betahydroxybutyrate (BHB).
- The ketogenic diet consists of 70-80% fats, 20-25% protein, and 5-10% carbohydrates.
• Medically, the ketogenic diet is utilized in patients with epilepsy and recommended by some physicians to improve general health through weight loss and insulin sensitivity.
• Key factors of neurodegeneration include glucose hypometabolism, oxidative damage, and neuroinflammation.
- Studies have shown that with ingestion of exogenous ketones alone, or endogenous ketonemia through a ketogenic diet, there is: bypassing of glucose utilization, restored metabolism, and production of anti-inflammatory proteins.
- Additionally, through multiple biochemical mechanisms, patients placed on exogenous ketones or fed a ketogenic diet have improved cognition in multiple domains.
• A proposed mechanism for improving memory loss and cognitive impairment in long term and rehabilitative care settings includes administration of either betahydroxybutyrate or prescription of a ketogenic diet.
Keywords
Ketogenic Diet, Cognitive Dysfunction, Health Care Facilities, Ketone Bodies, 3-Hydroxybutyric Acid
Disciplines
Alternative and Complementary Medicine | Biochemical Phenomena, Metabolism, and Nutrition | Lipids | Medical Nutrition | Medicine and Health Sciences | Neurology | Pathological Conditions, Signs and Symptoms
Document Type
Poster
Included in
Alternative and Complementary Medicine Commons, Biochemical Phenomena, Metabolism, and Nutrition Commons, Lipids Commons, Medical Nutrition Commons, Neurology Commons, Pathological Conditions, Signs and Symptoms Commons
Improvement of Memory Loss Through Dietary Intervention in the Assisted Living and Rehabilitative Settings
• The ketogenic diet is a popular, controversial diet that fuels the brain through beta-oxidation of fatty acids and production of ketone bodies, the most populous of which is betahydroxybutyrate (BHB).
- The ketogenic diet consists of 70-80% fats, 20-25% protein, and 5-10% carbohydrates.
• Medically, the ketogenic diet is utilized in patients with epilepsy and recommended by some physicians to improve general health through weight loss and insulin sensitivity.
• Key factors of neurodegeneration include glucose hypometabolism, oxidative damage, and neuroinflammation.
- Studies have shown that with ingestion of exogenous ketones alone, or endogenous ketonemia through a ketogenic diet, there is: bypassing of glucose utilization, restored metabolism, and production of anti-inflammatory proteins.
- Additionally, through multiple biochemical mechanisms, patients placed on exogenous ketones or fed a ketogenic diet have improved cognition in multiple domains.
• A proposed mechanism for improving memory loss and cognitive impairment in long term and rehabilitative care settings includes administration of either betahydroxybutyrate or prescription of a ketogenic diet.