Date of Presentation

5-5-2022 12:00 AM

College

School of Osteopathic Medicine

Poster Abstract

• The ketogenic diet is a popular, controversial diet that fuels the brain through beta-oxidation of fatty acids and production of ketone bodies, the most populous of which is betahydroxybutyrate (BHB).

  • The ketogenic diet consists of 70-80% fats, 20-25% protein, and 5-10% carbohydrates.

• Medically, the ketogenic diet is utilized in patients with epilepsy and recommended by some physicians to improve general health through weight loss and insulin sensitivity.

• Key factors of neurodegeneration include glucose hypometabolism, oxidative damage, and neuroinflammation.

  • Studies have shown that with ingestion of exogenous ketones alone, or endogenous ketonemia through a ketogenic diet, there is: bypassing of glucose utilization, restored metabolism, and production of anti-inflammatory proteins.
  • Additionally, through multiple biochemical mechanisms, patients placed on exogenous ketones or fed a ketogenic diet have improved cognition in multiple domains.

• A proposed mechanism for improving memory loss and cognitive impairment in long term and rehabilitative care settings includes administration of either betahydroxybutyrate or prescription of a ketogenic diet.

Keywords

Ketogenic Diet, Cognitive Dysfunction, Health Care Facilities, Ketone Bodies, 3-Hydroxybutyric Acid

Disciplines

Alternative and Complementary Medicine | Biochemical Phenomena, Metabolism, and Nutrition | Lipids | Medical Nutrition | Medicine and Health Sciences | Neurology | Pathological Conditions, Signs and Symptoms

Document Type

Poster

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May 5th, 12:00 AM

Improvement of Memory Loss Through Dietary Intervention in the Assisted Living and Rehabilitative Settings

• The ketogenic diet is a popular, controversial diet that fuels the brain through beta-oxidation of fatty acids and production of ketone bodies, the most populous of which is betahydroxybutyrate (BHB).

  • The ketogenic diet consists of 70-80% fats, 20-25% protein, and 5-10% carbohydrates.

• Medically, the ketogenic diet is utilized in patients with epilepsy and recommended by some physicians to improve general health through weight loss and insulin sensitivity.

• Key factors of neurodegeneration include glucose hypometabolism, oxidative damage, and neuroinflammation.

  • Studies have shown that with ingestion of exogenous ketones alone, or endogenous ketonemia through a ketogenic diet, there is: bypassing of glucose utilization, restored metabolism, and production of anti-inflammatory proteins.
  • Additionally, through multiple biochemical mechanisms, patients placed on exogenous ketones or fed a ketogenic diet have improved cognition in multiple domains.

• A proposed mechanism for improving memory loss and cognitive impairment in long term and rehabilitative care settings includes administration of either betahydroxybutyrate or prescription of a ketogenic diet.

 

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