College
Rowan-Virtua School of Osteopathic Medicine
Keywords
Alzheimer's Disease, Caffeine, Mechanisms, Neuroprotective, Literature Review
Date of Presentation
5-1-2025 12:00 AM
Poster Abstract
Background: This review aims to examine the molecular mechanisms through which caffeine may exert neuroprotective effects against Alzheimer’s Disease (AD).
Methods: A literature review was done across PubMed and Embase to identify studies between 2000 and 2024, exploring the mechanism behind caffeine’s effects on AD. The criteria focused on peer-reviewed articles involving human or animal models. Information was gathered on study design, participant characteristics, caffeine consumption, proposed mechanisms, and effects on cognition.
Results: The studies support caffeine's potential as a therapeutic, neuromodulator against AD through six mechanisms: inhibition of adenosine A2A receptors, decreased amyloid-beta production and aggregation, promotion of amyloid beta clearance, prevention of aberrant tau phosphorylation, induction of hippocampal neurogenesis, downregulation of AD-associated genes, and upregulation of an anti-inflammatory microglial phenotype.
Discussion: We define six key neuroprotective mechanisms of caffeine against AD, which will allow us to understand the pathology of AD, and help us develop novel treatments. Future research on this topic should prioritize exploring these high-evidence mechanisms in human subjects studies.
Disciplines
Chemical Actions and Uses | Geriatrics | Heterocyclic Compounds | Medicine and Health Sciences | Nervous System Diseases | Neurology
Included in
Chemical Actions and Uses Commons, Geriatrics Commons, Heterocyclic Compounds Commons, Nervous System Diseases Commons, Neurology Commons
Mechanisms Mediating the Protective Effects of Caffeine on Alzheimer’s Disease Progression
Background: This review aims to examine the molecular mechanisms through which caffeine may exert neuroprotective effects against Alzheimer’s Disease (AD).
Methods: A literature review was done across PubMed and Embase to identify studies between 2000 and 2024, exploring the mechanism behind caffeine’s effects on AD. The criteria focused on peer-reviewed articles involving human or animal models. Information was gathered on study design, participant characteristics, caffeine consumption, proposed mechanisms, and effects on cognition.
Results: The studies support caffeine's potential as a therapeutic, neuromodulator against AD through six mechanisms: inhibition of adenosine A2A receptors, decreased amyloid-beta production and aggregation, promotion of amyloid beta clearance, prevention of aberrant tau phosphorylation, induction of hippocampal neurogenesis, downregulation of AD-associated genes, and upregulation of an anti-inflammatory microglial phenotype.
Discussion: We define six key neuroprotective mechanisms of caffeine against AD, which will allow us to understand the pathology of AD, and help us develop novel treatments. Future research on this topic should prioritize exploring these high-evidence mechanisms in human subjects studies.