Date Approved

8-25-2021

Embargo Period

9-7-2021

Document Type

Thesis

Degree Name

M.S. Pharmaceutical Sciences

Department

Chemistry and Biochemistry

College

College of Science & Mathematics

Advisor

Gustavo Moura-Letts Ph.D.

Committee Member 1

Subash Jonnalagadda Ph.D.

Committee Member 2

Kandalam Ramanujachary Ph.D.

Keywords

hexahydrobenzofuranones, pyrrolidines, pyrrolines, azepines, vinyl oxaziridines

Subject(s)

Organic compounds--Synthesis

Disciplines

Medicinal and Pharmaceutical Chemistry

Abstract

One of the main goals in the GML lab group is the development of novel, economical, and environmentally friendly organic methods for the synthesis of pharmacologically relevant molecular moieties. The most salient pieces of data to the GML lab group members, reading dependable organic journals, are finding organic moieties that are largely unexplored, finding organic moieties which various research groups are having difficulty synthesizing, and finding complex organic procedures to key organic structures that can be easily reduced, or reconstructed, into novel methods that are more economical and environmentally friendly. By looking at these unexplored molecules, as well as hard to reach organic moieties, the GML lab group employs various organic methods to break down the target moiety at hand in order to recreate these compounds using superior novel methodologies. In my time working within the GML lab group , I successfully introduced a novel synthesis route for the Lewis acid catalyzed synthesis of hexahydrobenzofuranones, a selective synthesis of pyrrolidines, pyrrolines, and azepines from haloaziridines, and a photoisomerization reaction of vinyl oxaziridines from vinyl nitrones. It is the hope of the GML lab to use these synthetic strategies, and the respective synthesis routes developed from them, to improve on existing synthetic organic chemistry through reactions which rely on mild conditions to afford crucial organic moieties.

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