Date Approved

4-16-2024

Embargo Period

4-16-2024

Document Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Biomedical Engineering

College

Rowan-Virtua School of Translational Biomedical Engineering & Sciences

Advisor

Erik Brewer, Ph.D.

Committee Member 1

Vince Beachley, Ph.D.

Committee Member 2

Sebastián Vega, Ph.D.

Keywords

burst; composite; diabetes; drug delivery; hydrogel; microparticles

Subject(s)

Drugs---Design

Disciplines

Biomedical Engineering and Bioengineering | Pharmacy and Pharmaceutical Sciences

Abstract

Current drug-eluting coatings have demonstrated controlled long-term, sustained release but have only tried to mitigate short-term burst release as a negative side effect. For applications like wound healing, there is a need for a drug-eluting coating which is adjustable in both short- and long-term release, independent of each other. We present a tunable dual-phase dual-drug delivery coating composed of drug-loaded polymer microparticles and drug-loaded hydrogel which can control short term and long term release individually in this study. This coating was created using lidocaine and dexamethasone encapsulated in poly(D,L-lactide-co-glycolide) particles combined with lidocaine- and dexamethasone-loaded poly(vinyl alcohol) hydrogel. Hydrogel drug concentration and microparticle mass fraction were investigated for their impact on short-term and long-term release, respectively. A two week- long drug release study was performed with formulations varying only hydrogel drug concentration and only microparticle mass fraction. The results of this study show that PVA hydrogel drug concentration can control short-term release independently and drug-loaded PLGA particle mass fraction may control long-term release. This drug-eluting composite could extend the wear time of insulin infusion sets.

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